Pms2;

Mismatch repair endonuclease PMS2;

PMS1 protein homolog 2;DNA mismatch repair protein PMS2;

Mouse (Mus musculus). 

Heterodimer of PMS2 and Mlh1 (MutL alpha). Forms a ternary complex with MutS alpha (Msh2-Msh6) or MutS beta (Msh2-Msh3). Interacts with MTMR15/FAN1.

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with Mlh1 to form MutL alpha. DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (Msh2-Msh6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MulL alpha (Mlh1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.

Nucleus

859

N/A

Please Sign in.

PF01119

P54279

P54279

Mm.2950